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Neuronal Hyperexcitability: The Elusive Link Between Social Dysfunction and Biological Dysfunction

Received: 5 August 2022     Accepted: 23 August 2022     Published: 31 August 2022
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Abstract

Human society is a macrocosm of the human body. Hence, it should not be surprising that a physiological abnormality that can disrupt virtually every system of the human body can disrupt virtually aspect of human society. According to the multi-circuit neuronal hyperexcitability (MCNH) hypothesis of psychiatric disorders, an inherent hyperexcitability of the neurological system drives the wide range of psychological, emotional, and behavioral disturbances that together are referred to as “mental illness.” It also drives the plethora of autonomic, endocrinologic, metabolic, and immunologic disturbances that have been linked to mental illness. The means by which the neuronal hyperexcitability trait has these diverse effects is that a pathological elevation in neural signaling causes chaotic electrical signals to be sent both to the mind and to the various organs and systems of the body. The chaotic signaling to the mind causes the mental, emotional, and behavioral problems, and the chaotic signaling to the body causes the chronic medical problems with which the trait is associated. But beyond these effects, the neuronal hyperexcitability trait drives nearly every major social problem in society, including domestic violence, child abuse, abortion, substance misuse, unemployment, homelessness, and criminality. The means by which the trait drives all of these social problems is the same as that by which it drives all of the aforementioned psychiatric and medical problems because human society is made of billions of human beings, and nearly half of the world’s population harbors the trait of neuronal hyperexcitability. This article will take a detailed look at how the common but elusive trait of neuronal hyperexcitability translates into all of the psychiatric, medical, and social problems that have been plaguing humanity since antiquity and offer a practical intervention that has the potential to change the world.

Published in World Journal of Public Health (Volume 7, Issue 3)
DOI 10.11648/j.wjph.20220703.12
Page(s) 99-110
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Neuronal Hyperexcitability, Pathophysiology of Mental Illness, Mind-Body Connection, Biomarkers of Disease, Preventive Medicine, Anticonvulsants, Mood Stabilizers, Neuroregulators

References
[1] Binder MR. The multi-circuit neuronal hyperexcitability hypothesis of psychiatric disorders. AJCEM 2019; 7 (1): 12-30.
[2] Binder MR. FLASH syndrome: tapping into the root of chronic illness. AJCEM 2020; 8 (6): 101-109.
[3] Binder MR: The Neuronal Excitability Spectrum: a new paradigm in the diagnosis, treatment, and prevention of mental illness and its relation to chronic disease. AJCEM; 2021; 9 (6); 187-203.
[4] Binder MR. Mind-Brain Dynamics in the Pathophysiology of Psychiatric Disorders. AJPN 2022; 10 (2): 48-62.
[5] Pockett S. The electromagnetic field theory of consciousness: A testable hypothesis about the characteristics of conscious as opposed to non-conscious fields. Journal of Consciousness Studies 2012; 19 (11-12): 191-223.
[6] McFadden J. Synchronous firing and its influence on the brain’s electromagnetic field: Evidence for an electromagnetic theory of consciousness. JCS 2002; 9 (4): 23–50.
[7] Forbes N, Mahon B. Faraday, Maxwell, and the electromagnetic field: How two men revolutionized physics. Prometheus Books, New York, 2014.
[8] Anastassiou CA, Perin R, Markram H, Koch C. Ephaptic coupling of cortical neurons. Nat Neurosci 2011; 14 (2): 217-223.
[9] Cerf M, Thiruvengadam N, Mormann F, et al. On-line, voluntary control of human temporal lobe neurons. Nature 2010; 467: 1104-1108.
[10] Penfield W. Epilepsy and surgical therapy. Archives of Neurology and Psychiatry 1936; 36 (3): 449-484.
[11] Ferreira MAR, O’Donovan MC, Sklar P. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40 (9): 1056-1058.
[12] Yuan A, Yi Z, Wang Q, et al. ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. Am J Med Genet B Neuropsychiatr Genet 2012; 159B (8): 997-1005.
[13] Green EK, Grozeva D, Jones I, et al., Wellcome Trust Case Control Consortium, Holmans, PA, Owen, MJ, O'Donovan, MC, Craddock N. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2010; 15 (10): 1016-1022.
[14] Lopez AY, Wang X, Xu M, et al. Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. Mol Psychiatry 2017; 22 (10): 1464–1472.
[15] Post RM. Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena. Neuroscience & Biobehavioral Reviews 2007; 31 (6): 858-873.
[16] Azevedo FA, Carvalho LR, Herculano-Houzel S, et al. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 2009; 10; 513 (5): 532-541.
[17] Nguyen T. Total number of synapses in the adult human neocortex. Undergraduate Journal of Mathematical Modeling: One + Two 2010; 3 (1): Article 14.
[18] Kramlinger KG, Post RM. Ultra-rapid and ultradian cycling in bipolar affective illness. Br J Psychiatry. 1996 Mar; 168 (3): 314-23.
[19] Segal NL. Twins Reared Together and Apart: The Science Behind the Fascination. Proceedings from the American Philosophical Society 2017; 161 (1).
[20] Yizhar O, Fenno LE, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 2011; 477: 171-178.
[21] Hargreave E. (2006). The neuroplasticity phenomenon of kindling. http://hargreaves.swong.webfactional.com/kindle.htm. (Accessed 5/19/18).
[22] Wang M, Ramos BP, Paspalas, CD, et al. Alpha2A- adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 2007; 129 (2): 397-410.
[23] Erlij D, Acosta-García J, Rojas-Márquez M, et al. Dopamine D4 receptor stimulation in GABAergic projections of the globus pallidus to the reticular thalamic nucleus and the substantia nigra reticulata of the rat decreases locomotor activity. Neuropharmacology 2012; 62 (2): 1111-1118.
[24] Rose GM, Diamond DM, Pang K, Dunwiddie TV. Primed burst potentiation: lasting synaptic plasticity invoked by physiologically patterned stimulation. In: Haas HL, Buzsàki G. (eds) Synaptic plasticity in the hippocampus. Springer, Berlin, Heidelberg, 1988.
[25] Henkel AW, Welzel O, Groemer T W, et al. Fluoxetine prevents stimulation-dependent fatigue of synaptic vesicle exocytosis in hippocampal neurons. Journal of Neurochemistry 2010; 114 (3): 697-705.
[26] Brådvik L. Suicide Risk and Mental Disorders. Int J Environ Res Public Health 2018; 15 (9): 2028.
[27] Arsenault-Lapierre G, Kim C, Turecki G. Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry 2004; 4: 37.
[28] Schreiber J, Culpepper L. Suicidal ideation and behavior in adults. www.uptodate.com 2022.
[29] American Psychological Association. Stress in America 2020. A national mental health crisis. https://www.apa.org/news/press/releases/stress/2020/report-october.
[30] Latvala A, Kuja-Halkola R, Rick C, et al. Association of resting heart rate and blood pressure in late adolescence with subsequent mental disorders: A longitudinal population study of more than 1 million men in Sweden. JAMA Psychiatry 2016; 73 (12): 1268-1275.
[31] Blom EH, Serlachius E, Chesney MA, Olsson EMG. Adolescent girls with emotional disorders have a lower end-tidal CO2 and increased respiratory rate compared with healthy controls. Psychophysiology 2014; 51 (5): 412-418.
[32] Lee DH, de Rezende LFM, Hu FB, Jeon JY, Giovannucci EL. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes Metab Res Rev 2019; 35 (2): e3095.
[33] Aune D, o’Hartaigh B, Vatten LJ. Resting heart rate and the risk of type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis 2015; 25 (6): 526-534.
[34] Colangelo LA, Yano Y, Jacobs Jr DR, Lloyd-Jones DM. Association of resting heart rate with blood pressure and incident hypertension over 30 years in black and white adults: The CARDIA study. Hypertension 2020; 76 (3): 692-698.
[35] Shi Y, Zhou W, Liu S, et al. Resting heart rate and the risk of hypertension and heart failure: A dose-response meta-analysis of prospective studies. J Hypertens 2018; 36 (5): 995-1004.
[36] Cooney MT, Vartiainen E, Laatikainen T, et al. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J 2010; 159 (4): 612-619.
[37] Khan H, Kunutsor S, Kalogeropoulos AP, et al. Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis. J Am Heart Assoc 2015; 4 (1): e001364.
[38] Yu J, Dai L, Zhao Q. Association of cumulative exposure to resting heart rate with risk of stroke in general population: The Kailuan cohort study. Journal of Stroke and Cardiovascular Diseases 2017; (26): 11: 2501-2509.
[39] Huang Y-Q, Shen G, Huang J-Y, Zhang B, Feng Y-Q. A nonlinear association between resting heart rate and ischemic stroke among community elderly hypertensive patients. Postgrad Med 2020; 132 (2): 215-219.
[40] Anker MS, Ebner N, Hildebrandt B, et al. Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non-small cell lung cancer: results of a prospective cardiovascular long-term study. European Journal of Heart Failure 2016; 18 (12).
[41] Park J, Kim JH, Park Y. Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. PLoS One 2018; 13 (3): e0193753.
[42] Burke SL. Resting heart rate moderates the relationship between neuropsychiatric symptoms, MCI, and Alzheimer’s disease. Innov Aging 2019; 3 (suppl 1): S641.
[43] Aune D, Sen A, o’Hartaigh B, et al. Resting heart rate and the risk of cardiovascular disease, total cancer, and all-cause mortality - A systematic review and dose-response meta-analysis of prospective studies. Nutr Metab Cardiovasc Dis 2017; 27 (6): 504-517.
[44] Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta- analysis. CMAJ 2016; 188 (3): E53-E63.
[45] Baumert M, Linz D, Stone K, et al. Mean nocturnal respiratory rate predicts cardiovascular and all-cause mortality in community-dwelling older men and women. European Respiratory Journal 2019; DOI: 10.1183/13993003.02175-2018.
[46] Jouven X, Empana J-P, Schwartz PJ, et al. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 2005; 352: 1951-1958.
[47] Binder MR. Neuronal hyperexcitability: The elusive but modifiable instigator of disease. AJCEM 2022; 10 (1): 1-7.
[48] Binder MR. Gabapentin—the popular but controversial anticonvulsant drug may be zeroing in on the pathophysiology of disease. AJCEM 2021; 9 (4): 122-134.
[49] Binder MR. Introducing the term “Neuroregulator” in psychiatry. AJCEM 2019; 7 (3): 66-70.
[50] Binder MR. Focused neuroregulation in the treatment and prevention of mental and physical illness. AJCEM 2022; 10 (2): 49-58.
[51] Malhi GS, Bell E, Bassett D, et al. The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Aust N Z J Psychiatry 2021; 55 (1): 7-117.
[52] Zarate CA Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006; 63 (8): 856-864.
[53] Gunduz-Bruce, Silber C, Kaul I, et al. Trial of SAGE-217 in patients with major depressive disorder. N Engl J Med 2019; 381: 903-911.
[54] Binder MR. Symptom instability as a predictor of response to mood stabilizers [Unpublished manuscript]. Waukesha Memorial Hospital Department of Psychiatry 2005.
[55] Kelland K. Mental health crisis could cost the world $16 trillion by 2030. LONDON (Reuters) 2018.
Cite This Article
  • APA Style

    Michael Raymond Binder. (2022). Neuronal Hyperexcitability: The Elusive Link Between Social Dysfunction and Biological Dysfunction. World Journal of Public Health, 7(3), 99-110. https://doi.org/10.11648/j.wjph.20220703.12

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    ACS Style

    Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive Link Between Social Dysfunction and Biological Dysfunction. World J. Public Health 2022, 7(3), 99-110. doi: 10.11648/j.wjph.20220703.12

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    AMA Style

    Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive Link Between Social Dysfunction and Biological Dysfunction. World J Public Health. 2022;7(3):99-110. doi: 10.11648/j.wjph.20220703.12

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  • @article{10.11648/j.wjph.20220703.12,
      author = {Michael Raymond Binder},
      title = {Neuronal Hyperexcitability: The Elusive Link Between Social Dysfunction and Biological Dysfunction},
      journal = {World Journal of Public Health},
      volume = {7},
      number = {3},
      pages = {99-110},
      doi = {10.11648/j.wjph.20220703.12},
      url = {https://doi.org/10.11648/j.wjph.20220703.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220703.12},
      abstract = {Human society is a macrocosm of the human body. Hence, it should not be surprising that a physiological abnormality that can disrupt virtually every system of the human body can disrupt virtually aspect of human society. According to the multi-circuit neuronal hyperexcitability (MCNH) hypothesis of psychiatric disorders, an inherent hyperexcitability of the neurological system drives the wide range of psychological, emotional, and behavioral disturbances that together are referred to as “mental illness.” It also drives the plethora of autonomic, endocrinologic, metabolic, and immunologic disturbances that have been linked to mental illness. The means by which the neuronal hyperexcitability trait has these diverse effects is that a pathological elevation in neural signaling causes chaotic electrical signals to be sent both to the mind and to the various organs and systems of the body. The chaotic signaling to the mind causes the mental, emotional, and behavioral problems, and the chaotic signaling to the body causes the chronic medical problems with which the trait is associated. But beyond these effects, the neuronal hyperexcitability trait drives nearly every major social problem in society, including domestic violence, child abuse, abortion, substance misuse, unemployment, homelessness, and criminality. The means by which the trait drives all of these social problems is the same as that by which it drives all of the aforementioned psychiatric and medical problems because human society is made of billions of human beings, and nearly half of the world’s population harbors the trait of neuronal hyperexcitability. This article will take a detailed look at how the common but elusive trait of neuronal hyperexcitability translates into all of the psychiatric, medical, and social problems that have been plaguing humanity since antiquity and offer a practical intervention that has the potential to change the world.},
     year = {2022}
    }
    

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Author Information
  • Department of Psychiatry, NorthShore University HealthSystem, Highland Park Hospital, Highland Park, USA

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